To date, many different studies have been done using Glucosamine ingredients. However, not many people know that there are different types of Glucosamine's - Glucosamine Sulfate and Glucosamine Hydrochloride and even different types of stabilizations. All seem similar but are vastly different. Studies on Glucosamine have used both ingredients with different stabilizations at different quality levels, causing inconsistent results and some failed studies. This is what has added to the ever-growing question, does Glucosamine work?
Yes, it works. The more positive and clinically relevant studies have shown that high quality (pharmaceutical/USP grade) Glucosamine Sulfate at 1,500 mg dosage is more effective in supporting joint health. This is why Glucosamine Sulfate is considered to be one of the most popular and proven ingredients used to help with joint discomfort. Leading medical journals have cautioned that without head-to-head trials, other glucosamine products, like Glucosamine hydrochloride (HCI), may not provide the same benefits as Glucosamine Sulfate.
As a natural ingredient, Glucosamine Sulfate is essential in maintaining cartilage in the joints while defending, strengthening, and promoting overall joint flexibility. Glucosamine Sulfate has also been investigated for its ability to modify underlying cartilaginous degeneration in joints, and therefore to potentially provide relief to patients. The majority of studies have demonstrated the ability of Glucosamine Sulfate to alleviate symptoms of joint discomfort due to overexertion and exercise as well as support joint function and cartilage. Glucosamine Sulfate has been used in many pre-clinical and clinical studies.